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48
Oct 16, 2014
10/14
by
Klug, Yoel A.; Ashkenazi, Avraham; Viard, Mathias; Porat, Ziv; Blumenthal, Robert; Shai, Yechiel
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This article is from Biochemical Journal , volume 461 . Abstract Lipid-conjugated peptides have advanced the understanding of membrane protein functions and the roles of lipids in the membrane milieu. These lipopeptides modulate various biological systems such as viral fusion. A single function has been suggested for the lipid, binding to the membrane and thus elevating the local concentration of the peptide at the target site. In the present paper, we challenged this argument by exploring...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072049
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58
Oct 28, 2014
10/14
by
Kim, Taejin; Afonin, Kirill A.; Viard, Mathias; Koyfman, Alexey Y; Sparks, Selene; Heldman, Eliahu; Grinberg, Sarina; Linder, Charles; Blumenthal, Robert P; Shapiro, Bruce A
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This article is from Molecular Therapy. Nucleic Acids , volume 2 . Abstract Specific small interfering RNAs (siRNAs) designed to silence different oncogenic pathways can be used for cancer therapy. However, non-modified naked siRNAs have short half-lives in blood serum and encounter difficulties in crossing biological membranes due to their negative charge. These obstacles can be overcome by using siRNAs complexed with bolaamphiphiles, consisting of two positively charged head groups that flank...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615820
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3.0
Sep 5, 2019
09/19
by
HuffPost Politics
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President Trump this week spoke of "very fine people" among the Nazis and Ku Klux Klanners who staged a violent protest that resulted in the deaths of three people on Saturday. Trump's comments drew cascades of condemnation, but we already knew he had white supremacist tendencies. Jamelle Bouie, the chief political correspondent for Slate.com, joins So That Happened to talk about what has really changed, and whether Nazis are now in a real position of power. Also, HuffPost reporter...
